DSIP

DSIP promotes delta-wave sleep and modulates HPA axis responses in rats under chronic stress^[1]

The original characterization study and subsequent replications examined DSIP's sleep-promoting and stress-axis modulatory properties in rats. Intraventricular DSIP significantly increased slow-wave (delta) sleep duration and depth as measured by EEG power spectral analysis, while reducing paradoxical (REM) sleep latency without altering total sleep time. DSIP also attenuated plasma corticosterone elevations following restraint stress, suggesting inhibitory activity at the level of the hypothalamic-pituitary-adrenal axis. Somatostatin release from hypothalamic slice preparations was inhibited by DSIP in vitro, consistent with DSIP's proposed role as a disinhibitor of GH pulsatility during sleep.

Last verified: 2026-04-03

Effects of DSIP on cortisol and ACTH secretion in healthy volunteers — a double-blind crossover study^[2]

This double-blind, placebo-controlled crossover research study in ten healthy male volunteers evaluated DSIP intravenously at 30 nmol/kg and measured hormonal responses over six hours. DSIP produced a modest but statistically significant reduction in cortisol and ACTH plasma concentrations compared to saline, with maximum effects at 90 minutes post-infusion. Sleep structure was monitored by ambulatory EEG and showed a significant increase in slow-wave sleep percentage in the DSIP condition. No adverse effects were recorded at the concentration studied, and GH secretion showed a non-significant trend toward increase during the first nocturnal sleep period.

Last verified: 2026-04-03